Filled by a licensed US pharmacy we chose. See which one
Estradiol tablet, taken by mouth
Compounded estradiol in a tablet you take by mouth on the schedule your provider sets. Prescribed by a Seattle provider and filled by a licensed US pharmacy we chose.
With the 3-month plan. $59 month to month.
You only pay if a provider prescribes.
Every prescription gives 50 meals a month to those in need.
Estradiol is the main estrogen your ovaries made before menopause. A tablet you swallow is absorbed through your gut and passes through your liver before it reaches the rest of your body.
The FDA label for estradiol tablets lists treatment of moderate to severe hot flashes associated with menopause.
The label also lists moderate to severe vaginal and vulvar symptoms of menopause. For those symptoms alone, it says to consider a vaginal product.
Prefer estrogen through your skin? See estradiol patch
The FDA label for estradiol tablets describes a usual starting range of 1 to 2 mg a day, adjusted to control symptoms, often in cycles such as 3 weeks on and 1 week off. Your provider sets your dose and schedule with you, and your pharmacy label shows them.
Tablet days
A week off, if your schedule has one
Tablet dayNo tablet
Your pharmacy label shows your schedule
Take your tablet at about the same time each day, like with breakfast or when you brush your teeth.
Your pharmacy label shows your dose and whether your schedule includes a week off.
Message your provider in your patient portal about what to do. Don't take extra tablets to catch up unless your provider tells you to.
Keep the bottle closed, out of reach of children, and check the beyond-use date on your pharmacy label.
The label suggests talking with your provider about your dose and whether you still need treatment, for example every 3 to 6 months.
Dosing as described in the FDA label for estradiol tablets USP, the generic of Estrace. Compounded estradiol tablets are not FDA approved. Your provider's directions and your pharmacy label come first.
Estradiol tablets were approved by the FDA as the brand-name drug Estrace, now sold as generic estradiol tablets. The label for estradiol tablets reports a two-year trial on bone, and it does not include hot flash trial results. Compounded estradiol tablets were not the product studied.
In a two-year trial, 0.5 mg of estradiol a day, for 23 days of each 28-day cycle, prevented bone loss in the spine compared with placebo.
A randomized, double-blind, placebo-controlled trial described in the FDA label. The label says to consider estrogen for bone only for women at significant risk who cannot use non-estrogen medicines.
Estradiol tablets USP prescribing information, clinical studies, DailyMed.For women younger than 60, or within 10 years of menopause onset, with no contraindications, the statement calls the benefit-risk ratio of hormone therapy favorable for bothersome hot flashes and preventing bone loss.
It adds that the risks differ by type, dose, how long you take it, route, when you start and whether a progestogen is used, and calls the benefit-risk ratio less favorable when therapy starts after 60 or more than 10 years from menopause.
The 2022 hormone therapy position statement, Menopause 2022. PubMed.Neither source tested compounded estradiol tablets. Compounded medications are not FDA approved, and the FDA does not review them for safety, effectiveness or quality. Individual results vary.
The first weeks are about building the habit. Here's what happens, in order.
Your pharmacy ships your tablets to your door. Store them the way your pharmacy label says and check the beyond-use date.
Take your first tablet at a time of day you can stick with. Coming off a patch, gel or another estrogen? Your provider will tell you when to start.
Headache, breast pain, irregular vaginal bleeding or spotting, stomach cramps or bloating, nausea and vomiting, and hair loss are common side effects listed on the label.
If a side effect doesn't settle, message your provider in your patient portal.
Questions about your dose, your schedule or how you are feeling go to your provider in your patient portal. You can also book a video visit at no extra cost.
Your provider will talk with you about progesterone. The label says a progestin should be started along with estrogen for women with a uterus, to lower the chance of cancer of the uterine lining. See progesterone capsules
If your tablets or delivery look off, email hello@jointhebrightside.com before you take them.
For chest pain, shortness of breath, pain in your legs, changes in vision or speech, dizziness or fainting, vomiting, or a sudden severe headache.
From the FDA label for estradiol tablets USP. Your provider's directions and your pharmacy label come first.
We grade the pharmacies we work with in five categories. More than eighty compounding pharmacies have been through our grading so far.
A physician-led medical group. A licensed provider reviews every visit and every dose change.
The same providers, after you start
A licensed provider from Arora Health in Seattle reviews every visit and every dose change. Questions about your dose, side effects or what comes next go to them in your patient portal.
No. Compounded estradiol tablets are made by a state-licensed pharmacy for one patient, from a prescription. They are not FDA approved, and the FDA does not review compounded drugs for safety, effectiveness or quality.
No. Estrace was the FDA-approved brand of estradiol tablets, and FDA-approved generic estradiol tablets are sold today. We use the FDA label for estradiol tablets as the reference for the information on this page.
The label describes daily tablets, often in cycles such as 3 weeks on and 1 week off. Your provider chooses the schedule with you, and your pharmacy label shows it.
If you have a uterus, your provider will talk with you about progesterone. The label says a progestin should be started along with estrogen for women with a uterus. See progesterone capsules
In the ESTHER study, summarized by ACOG, women taking estrogen by mouth had higher odds of a blood clot in a vein than women not using estrogen, and women using estrogen through the skin did not. Your provider weighs your history with you. See estradiol patch
A licensed US pharmacy we chose. Our pharmacy network page names each pharmacy that fills orders today and its licenses.
Your pharmacy ships your tablets to your door. Store them the way the label says. If anything about your delivery looks off, email hello@jointhebrightside.com before you use it.
No. Insurance isn't needed, and your visit, online or on video, is included in the treatment price.
You're not charged. Your card is only charged if a licensed provider prescribes your treatment.
With the 3-month plan. $59 month to month.
You only pay if a provider prescribes.
Estrogens increase the chance of cancer of the lining of the uterus. Report any unusual vaginal bleeding to your provider right away so they can check the cause. If you have a uterus, your provider will talk with you about progesterone, which the label says should be started along with estrogen to lower that chance.
The label also carries a boxed warning on heart disease and other risks. Estrogens, with or without progestins, should not be used to prevent heart disease. In the Women's Health Initiative, women taking daily oral conjugated estrogens with medroxyprogesterone acetate had higher risks of heart attack, stroke, invasive breast cancer, blood clots in the lungs and blood clots in the legs, and women 65 and older had a higher risk of probable dementia. The label says these risks should be assumed to be similar for other estrogens and doses.
Tell your provider if you have or have had unusual vaginal bleeding, breast cancer or another estrogen-sensitive cancer, blood clots, a stroke or heart attack, liver problems, or an allergy to estradiol, and if you are or may be pregnant. Tell your provider about every medication and supplement you take, and before any surgery or bed rest.
Get medical help right away for chest pain, shortness of breath, pain in your legs, changes in vision or speech, dizziness or fainting, vomiting, or a sudden severe headache. Call your provider about a breast lump or unusual vaginal bleeding. Common side effects include headache, breast pain, irregular vaginal bleeding or spotting, stomach cramps or bloating, nausea and vomiting, and hair loss.
Based on the FDA prescribing information for estradiol tablets USP (Estrace is the original brand). Compounded estradiol tablets are not FDA approved, and the FDA does not review compounded drugs for safety, effectiveness or quality.
