Filled by a licensed US pharmacy we chose. See which one
Compounded progesterone, taken by mouth at bedtime
Progesterone in a capsule you swallow, taken alongside estrogen. Prescribed by a Seattle provider and filled by a licensed US pharmacy we chose.
With the 3-month plan. $55 month to month.
You only pay if a provider prescribes.
Every prescription gives 50 meals a month to those in need.
Progesterone is a hormone your body makes. The capsules are taken by mouth, alongside estrogen, by women with a uterus.
Estrogen alone can thicken the lining of the uterus, a condition called endometrial hyperplasia that may lead to cancer. The Prometrium label describes a trial in which adding Prometrium to estrogen lowered that chance compared with estrogen alone. Compounded progesterone was not the product studied.
Progesterone capsules may cause dizziness and drowsiness, so the Prometrium label says to take them as a single daily dose at bedtime.
Prefer one cream for both hormones? See biest cream with progesterone
The Prometrium label describes one dose at bedtime, 200 mg for 12 days in a row in each 28-day cycle, for a woman with a uterus who takes estrogen. Your provider sets your dose and schedule with you, and your pharmacy label shows exactly how many capsules to take and on which days.
Week 1
Week 2
Week 3
Week 4
Capsule at bedtimeNo capsule
The schedule on the Prometrium label. Yours is on your pharmacy label
Take your capsule as a single dose at bedtime, at about the same time each night.
If capsules are hard to swallow, the Prometrium label suggests taking yours with a glass of water while standing.
Progesterone can make you dizzy or drowsy. Be careful driving or using machinery until you know how it affects you.
Your pharmacy label shows whether you take it every night or on set days of each cycle. Store the capsules the way the label says.
Routine from the FDA prescribing information for Prometrium (progesterone capsules). Your provider's directions and your pharmacy label come first.
Progesterone capsules have been tested in clinical trials as the brand-name drug Prometrium, taken with conjugated estrogens. Our compounded capsules were not the product studied.
Share of women with endometrial hyperplasia over up to 36 months, in a randomized trial of 358 postmenopausal women with a uterus. Prometrium was taken at bedtime for 12 days of each 28-day cycle with conjugated estrogens.
Clinical studies section, Prometrium prescribing information.Both prefer FDA-approved hormone therapy when it is available.
The American College of Obstetricians and Gynecologists says: "Compounded bioidentical menopausal hormone therapy should not be prescribed routinely when FDA-approved formulations exist." It also gives an example of when compounding fits: progesterone made without the peanut oil in an FDA-approved capsule, for someone with a peanut allergy.
The Menopause Society's 2022 position statement lists safety concerns with compounded hormones, including minimal government regulation and overdosing or underdosing, and says they could be considered for an allergy to an ingredient or a dose that approved products don't offer.
ACOG Clinical Consensus No. 6, November 2023. The Menopause Society, Menopause, 2022.Results from the Prometrium trial do not predict results with compounded progesterone capsules, which are not FDA approved. The FDA does not review compounded drugs for safety, effectiveness or quality. Individual results vary.
The first weeks are about building the routine. Here's what happens, in order.
Your pharmacy ships your capsules to your door. Store them the way your pharmacy label says and keep them out of reach of children.
Take it when you're ready for bed, since it can make you dizzy or drowsy. Your label shows which days you take it.
Headache, breast pain, irregular spotting, bloating, nausea and dizziness are among the common side effects listed on the Prometrium label.
If side effects don't settle, message your provider in your patient portal.
Questions about your dose, your schedule or how it is going go to your provider in your patient portal. You can also book a video visit at no extra cost.
Tell your provider. Prometrium capsules contain peanut oil, and compounded capsules can be made without it. Your provider and pharmacy can confirm what is in yours.
Tell your provider before any surgery or if you will be on bed rest. They will let you know if you need to stop.
For changes in vision or speech, a sudden severe headache, severe pain in your chest or legs, with or without shortness of breath, or dizziness and fainting.
Side effects and warning signs from the FDA prescribing information for Prometrium (progesterone capsules). Your provider's directions and your pharmacy label come first.
We grade the pharmacies we work with in five categories. More than eighty compounding pharmacies have been through our grading so far.
A physician-led medical group. A licensed provider reviews every visit and every dose change.
The same providers, after you start
A licensed provider from Arora Health in Seattle reviews every visit and every dose change. Questions about your dose, side effects or what comes next go to them in your patient portal.
Prometrium, the brand-name progesterone capsule, is FDA approved. Our capsules are compounded, made by a state-licensed pharmacy for one patient from a prescription, so they are not FDA approved, and the FDA does not review compounded drugs for safety, effectiveness or quality.
The Prometrium label says progesterone capsules may cause dizziness and drowsiness, and that they should be taken as a single daily dose at bedtime.
Tell your provider. Prometrium contains peanut oil and should not be used by anyone allergic to peanuts. Compounded progesterone can be made without peanut oil, and your provider and pharmacy can confirm what is in yours.
Your provider sets your schedule. The Prometrium label describes 12 days in a row in each 28-day cycle alongside estrogen, and your pharmacy label shows your days.
The Prometrium label describes progesterone for a woman with a uterus who takes estrogen. Your provider decides with you what your plan includes. See biest cream or estradiol patch.
The capsule is progesterone on its own, taken by mouth. The cream puts estrogen and progesterone together on your skin. The FDA label data on the uterine lining comes from Prometrium, a brand-name capsule taken by mouth, not from compounded capsules or creams. Your provider can help you choose.
A licensed US pharmacy we chose. Our pharmacy network page names each pharmacy that fills orders today and its licenses.
Your pharmacy packs your capsules and ships them to your door. Store them the way the label says. If anything about your delivery looks off, email hello@jointhebrightside.com before you use them.
No. Insurance isn't needed, and your visit, online or on video, is included in the treatment price.
You're not charged. Your card is only charged if a licensed provider prescribes your treatment.
With the 3-month plan. $55 month to month.
You only pay if a provider prescribes.
Progesterone with estrogen. The current FDA prescribing information for Prometrium (progesterone capsules) does not carry a boxed warning. It describes increased risks of blood clots in the legs and lungs, stroke, heart attack and invasive breast cancer in a large study of a different estrogen plus progestin combination, and says the safety and effectiveness of estrogen plus progestogen for preventing heart disease have not been established.
Dizziness and drowsiness. Progesterone capsules may cause dizziness and drowsiness. Take them at bedtime and be careful driving or using machinery. Prometrium capsules contain peanut oil.
Tell your provider if you are allergic to peanuts, have unusual vaginal bleeding, have or have had breast cancer, blood clots, a stroke or heart attack, or liver problems, and if you are pregnant or breastfeeding. Tell your provider about every medication and supplement you take, and before any surgery or bed rest.
The estrogen you take with it has its own safety information, including a boxed warning on endometrial cancer for systemic estrogen used alone, which the FDA kept when it asked for labeling changes on November 10, 2025. Based on the FDA prescribing information for Prometrium (progesterone capsules), revised February 2026. Compounded progesterone capsules are not FDA approved, and the FDA does not review compounded drugs for safety, effectiveness or quality.
