Compounded by Nordic Pharmacy in Poulsbo, Washington
Bremelanotide nasal spray, used as needed
A sexual wellness medication that works in the brain on desire and arousal. Prescribed by a Seattle provider and made at Nordic Pharmacy in Poulsbo.
You only pay if a provider prescribes.
Ships to your door with directions from Nordic Pharmacy.
Every prescription gives 50 meals a month to those in need.
PT-141, also called bremelanotide, acts on melanocortin receptors in the brain, part of the system involved in sexual desire and arousal.
Works on signaling in the brain rather than on blood flow.
Those medications act on blood flow. PT-141 acts in the brain.
An injectable form of bremelanotide, Vyleesi, is FDA approved for premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). Compounded PT-141 is not Vyleesi and is not FDA approved.
PT-141 is used as needed, not every day. Your provider sets your dose, and your pharmacy label tells you how to use the spray.
Limits from the Vyleesi label
Used ahead of sexual activity. In the Vyleesi trials, the dose was taken at least 45 minutes before.
Nausea is the most common side effect. Your provider can adjust your dose or plan if it gets in the way.
Your provider looks at how it's working and how you're feeling before changing anything.
Message your provider in your patient portal, or book a video visit at no extra cost.
Limits and timing as described for Vyleesi (bremelanotide) injection. Your provider's directions and your pharmacy label come first.
Bremelanotide was tested in two large trials as Vyleesi, an injection. Compounded PT-141 was not the drug studied in these trials.
"VYLEESI improved sexual desire and decreased the level of feeling bothered by low sexual desire in comparison to placebo."
U.S. Food and Drug Administration, Drug Trials Snapshot: Vyleesi. Trials published by Kingsberg et al., Obstetrics & Gynecology, 2019.Bremelanotide was first developed as a nasal spray. That program stopped after some trial participants had increases in blood pressure, and the developer moved to an injection. The developer said:
"We believe this was due to variability in drug uptake with intranasal administration."
Palatin Technologies, as reported by Medical News Today.Results from Vyleesi trials do not predict results with compounded PT-141. Compounded medications are not FDA approved. Individual results vary.
Here's what happens from your visit to your first few uses.
Nordic Pharmacy ships your PT-141 to your door with directions. Store it the way the label says.
In the Vyleesi trials, nausea was the most common side effect, reported by 40% of women. Flushing and headache were next.
Bremelanotide can raise blood pressure and lower heart rate for a while after each dose. It isn't for people with uncontrolled high blood pressure or heart disease.
Tell your provider how it's going in your patient portal, including any side effects, so they can adjust your dose or your plan.
Some people get darker patches of skin, more often with frequent use. They may not fade after stopping.
Bremelanotide can briefly slow digestion, which can change how some pills are absorbed. Tell your provider everything you take.
For chest pain, a severe headache, or signs of an allergic reaction like swelling of your face, lips or throat.
Side effect details from FDA information for Vyleesi (bremelanotide), including the Drug Trials Snapshot and prescribing information. Your provider's directions and your pharmacy label come first.
A local compounding pharmacy filling prescriptions for patients in Washington and Oregon.
A physician-led medical group. A licensed provider reviews every visit and every dose change.
"I’m new to the medicine I’m taking and Nordic pharmacy made me so comfortable with starting it! The videos of how to administer it and the information they give you with every dose is supportive and informative."
No. Vyleesi is an FDA-approved bremelanotide injection. Compounded PT-141 is made by a state-licensed pharmacy for one patient, from a prescription. It is not FDA approved, and the FDA does not review compounded drugs for safety, effectiveness or quality.
Adults looking for help with sexual desire or arousal, when a provider decides it's appropriate. Vyleesi's approval covers premenopausal women with HSDD. Prescribing it for anyone else is up to your provider.
No. Sildenafil (Viagra) and tadalafil (Cialis) work on blood flow. PT-141 works in the brain, on desire and arousal.
No. It's used as needed. The Vyleesi label limits use to one dose in 24 hours and eight doses a month.
Nordic Pharmacy ships it from Poulsbo to your door with directions. Store it the way the label says.
No. Insurance isn't needed, and your visit, online or on video, is included in the treatment price.
You're not charged. Your card is only charged if a licensed provider prescribes your treatment.
Not yet. PT-141 is starting in Washington and Oregon, made at Nordic Pharmacy.
Do not use bremelanotide if you have high blood pressure that isn't controlled, or known heart disease. It can temporarily raise blood pressure and lower heart rate after each dose.
The most common side effects are nausea, flushing, headache and vomiting. Some people get darker patches of skin on the face, gums or breasts, more likely with frequent use, and it may not fade. Tell your provider about every medication you take, and if you are pregnant or could become pregnant.
Based on FDA information for Vyleesi (bremelanotide). Compounded PT-141 is not FDA approved.
